https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22647 Wed 22 May 2019 14:51:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48943 Wed 19 Apr 2023 13:52:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54058 Tue 30 Jan 2024 13:55:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43306 Thu 15 Sep 2022 13:54:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27223 M-H = 0.08). These results point to a role of the NLRP3 inflammasome and its related cytokine IL1B in the response to interferon beta in patients with relapsing-remitting multiple sclerosis.]]> Sat 24 Mar 2018 07:32:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38338 -4, hazard ratio = 1.41). Moreover, rs7298096AA is associated with a higher NINJ2 expression in blood (p = 7.0 x 10^-6), which was confirmed in vitro (p = 0.009). Finally, NINJ2 expression is downregulated by IFNβ treatment and related to TTFR. Conclusions: Rs7298096 could influence MS disease activity during IFNβ treatment by modulating NINJ2 expression in blood. The gene encodes for an adhesion molecule involved in inflammation and endothelial cells activation, supporting its role in MS.]]> Mon 30 Aug 2021 13:46:38 AEST ]]>